The restorative effect of ascorbic acid on liver injury inducedby asymmetric dimethylarginine

Authors :

Pages : 452-461

View : 9 | Download : 0

Publication Date : 2016-12-01

Article Type : Research Paper

Abstract :We aimed to determine whether increased levels of asymmetric dimethylarginine insert ignore into journalissuearticles values(ADMA); directly cause hepatic deterioration and whether it is decreased by ascorbic acid insert ignore into journalissuearticles values(AA); as an antioxidant. The study included three groups: Control insert ignore into journalissuearticles values(n = 10);, ADMA insert ignore into journalissuearticles values(n = 10);, and ADMA + AA insert ignore into journalissuearticles values(n = 10);. ADMA was administered at 2 mg kg-1 day-1 and AA was given at 50 mg kg-1 day-1 for 10 days. Serum aspartate aminotransferase insert ignore into journalissuearticles values(AST);, alanine aminotransferase insert ignore into journalissuearticles values(ALT);, gamma-glutamyl transferase, and alkaline phosphatase activities were analyzed. Histomorphological evaluation of the liver was performed based on the Ishak scoring system. When compared with the control, ALT and ALP levels of the ADMA group were significantly higher insert ignore into journalissuearticles values(P = 0.006 and P = 0.041, respectively);. When compared with the control, interface hepatitis, confluent necrosis, focal necrosis, histological activity index, severity of hepatitis, and portal inflammation were significantly higher in the group administered ADMA. The mentioned biochemical/histopathological parameters were lower in the ADMA + AA group when compared with the ADMA group even if no significant difference was encountered insert ignore into journalissuearticles values(P > 0.05);. The results indicate that ADMA is a factor in the formation of liver injury. Insufficient recovery in biochemical/histopathological parameters when AA was given make us consider that different factors other than prooxidant factors are effective in the formation of liver injury.
Keywords : Asymmetric dimethylarginine, ascorbic acid, Ishak score, alanine aminotransferase, alkaline phosphatase