TGF-β: Its role in the differentiation and function of T regulatory and effector cells

Authors : SUJUAN YANG, SONGGUO ZHENG

Pages : 1-11

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Publication Date : 2017-12-01

Article Type : Research Paper

Abstract :The cytokine transforming growth factor-β insert ignore into journalissuearticles values(TGF-β); plays an important role in the maintenance of T cell homeostasis, immune tolerance to self-antigens, and T cell differentiation during immune responses. TGF-β has pleiotropic effects on adaptive immune responses, especially on the differentiation of T helper and T regulatory cell populations, which depends on the T cell differentiation status and the stimulation conditions. This review provides an update about the roles of TGF-β in T cell responses, especially in the regulation of Treg development and biological features under steady state and inflammation. We also discuss the additional roles that TGF-β plays in the development and function of other T helper cells, such as Th1, Th2, Th9, Th17, and Th22 cells during inflammation.
Keywords : Transforming growth factor β, T helper cells, T regulatory cells