A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells

Authors : Didem KARAKAŞ, Remzi Okan AKAR, Zeliha GÖKMEN, Nahide Gülşah DENİZ, Engin ULUKAYA

Pages : 256-263

View : 21 | Download : 5

Publication Date : 2019-12-01

Article Type : Research Paper

Abstract :Breast cancer is the most-diagnosed cancer type among women. The triple-negative subtype is an especially aggressive type of breast cancer. Although chemotherapy is almost the only option for the treatment of triple-negative breast cancer insert ignore into journalissuearticles values(TNBC);, currently used chemotherapeutics are not effective enough, considering the poor survival rate of patients. Therefore, novel compounds need to be developed to improve survival rates. It has been known that quinonic compounds, which are found in nature, have antibacterial, antifungal, and antitumorigenic properties. Naphthoquinones are members of the quinone family and are widely used in research due to their promising properties. In this study, we evaluated the cytotoxic activity of a novel naphthoquinone-derived compound insert ignore into journalissuearticles values(1,4-naphthoquinone insert ignore into journalissuearticles values(1,4-NQ);); against two different breast cancer cells: a hormone-responsive cell line insert ignore into journalissuearticles values(MCF-7); and a triple-negative cell line insert ignore into journalissuearticles values(MDA-MB-231);. As a result, 1,4-NQ decreased cell viability in both tested cell lines in a dose-dependent manner. Increased apoptotic markers insert ignore into journalissuearticles values(presence of pyknotic nuclei, annexin-V positivity, caspase 3/7 activity, and decreased mitochondrial membrane potential); and DNA damage were especially observed in MDA-MB-231 cells after treatment with the compound. Considering the promising cytotoxic effect of the compound, 1,4-NQ needs further evaluation as a potential candidate for the treatment of TNBC.
Keywords : Quinones, 1, 4 naphthoquinones, cytotoxicity, apoptosis, triple negative breast cancer, anticancer agent