Synthesis, characterization, and biological activity studies of (E)-N`-((thiophen-2-yl)methylene)benzofuran-2-carbohydrazide and its metal(II) complexes

Authors : Madappa B. HALLI, Vijayalaxmi B. Patil And Sumathi R. BEVINAMARADA

Pages : 393-404

Doi:10.3906/sag-1207-108

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Metal complexes of the type MLX2, where M = Coinsert ignore into journalissuearticles values(II);, Niinsert ignore into journalissuearticles values(II);, Cuinsert ignore into journalissuearticles values(II);, Zninsert ignore into journalissuearticles values(II);, Cdinsert ignore into journalissuearticles values(II);, and Hginsert ignore into journalissuearticles values(II);, and X = Cl and L = TMBC, Schiff base derived from the condensation of benzofuran-2-carbohydrazide with thiophene-2-aldehyde were synthesized. The structure of the complexes was proposed in light of analytical, IR, UV-Vis, 1H-NMR, FAB-MS, ESR spectral data, and magnetic studies. The complexes were soluble in DMF and DMSO. The measured molar conductance values indicated that the complexes were nonelectrolytic in nature. On the basis of these studies, 6 coordinated octahedral polymeric structures were assigned to the Coinsert ignore into journalissuearticles values(II);, Niinsert ignore into journalissuearticles values(II);, and Cuinsert ignore into journalissuearticles values(II); complexes, and 4 coordinated tetrahedral geometries to the Zninsert ignore into journalissuearticles values(II);, Cdinsert ignore into journalissuearticles values(II);, and Hginsert ignore into journalissuearticles values(II); complexes. The Schiff base and its metal complexes were tested for antibacterial and antifungal activities by the MIC method. The DNA cleavage activities of all of the complexes were studied by the agarose gel electrophoresis method.
Keywords : Benzofuran, Schiff base, metal complexes, spectral studies, antimicrobial activity, DNA cleavage