Synthesis, characterization, crystal structures, and antibacterial activity of some new 1-(3,4,5-trimethoxybenzoyl)-3-aryl thioureasreas

Authors : Aamer SAEED, Rasheed Ahmad KHERA, Naeem ABBAS, Muhammad LATIF

Pages : 335-346

Doi:10.3906/sag-1206-11

View : 9 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Synthesis of some novel 1-insert ignore into journalissuearticles values(3,4,5-trimethoxy);benzoyl-3- arylthiourea derivatives insert ignore into journalissuearticles values(1a-o); was accomplished in 2 steps. The synthetic route involves the reaction of 1-insert ignore into journalissuearticles values(3,4,5-trimethoxy);benzoyl chloride with potassium thiocyanate in 1:1 molar ratio in acetone to afford the corresponding isothiocyante followed by treatment with suitably substituted anilines. The structures of the products were established by elemental analyses, IR, 1H- and 13C-NMR, and mass spectroscopy and for 1b and 1m from single crystal X-ray diffraction data. All of the synthesized compounds insert ignore into journalissuearticles values(1a-o); were screened for antibacterial activity against gram positive and gram negative bacterial strains and were found to exhibit low activity towards the tested microorganisms, compared to chloramphenicol, the standard drug.
Keywords : 1 3, 4, 5 trimethoxy, benzoyl 3 arylthioureas, antibacterial, crystal structure