Synthesis, characterization, antibacterial and antifungal evaluation of some new platinum(II) complexes of 2-phenylbenzimidazole ligands

Authors : Semra UTKU, Mustafa TOPAL, Aylin DÖĞEN

Pages : 427-436

View : 14 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of platinuminsert ignore into journalissuearticles values(II); complexes of the type [PtL2Cl2] 1, [PtL2I2] 2, [PtL2insert ignore into journalissuearticles values(oxalato);] 3, and [PtL2insert ignore into journalissuearticles values(malonato);] 4 insert ignore into journalissuearticles values(L= 2-phenylbenzimidazole ligands as ``non-leaving groups``); were synthesized and characterized by their elemental analyses, IR, 1H NMR, and ESI-LC/MS. The in vitro antimicrobial activity of the synthesized compounds has been evaluated by the macrodilution method against gram-positive bacteria, such as Staphylococcus aureus, Bacillus subtilis, and Enterococcus faecalis; gram-negative bacteria, such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonia; and yeast like fungi, such as Candida glabrata and Candida parapsilosis. In general, based on the data obtained in this study, synthesized complexes 1-4 might be taken into consideration as promising antifungal compounds.
Keywords : Antibacterial activity, antifungal activity, benzimidazole, carboxylato complexes, platinum II, complexes