Synthesis of some pyridazine derivatives carrying urea, thiourea, and sulfonamide moieties and their antimicrobial activity

Authors : Deniz S. DOĞRUER, Şölen URLU, Tijen ÖNKOL

Pages : 57-65

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Some pyridazine derivatives carrying urea, thiourea, and sulfonamide groups were synthesized and evaluated for their antimicrobial activity against gram-positive and gram-negative bacteria, and fungi by using broth microdilution. The structures of these new compounds were confirmed by 1H-NMR, mass spectrum, and elemental analysis. The synthesized compounds exhibited generally promising inhibitory activity against S. aureus insert ignore into journalissuearticles values(MIC ranging from 2 to 4 m g/mL); and E. coli insert ignore into journalissuearticles values(MIC ranging from 4 to 16 m g/mL);. Moreover, all compounds showed antifungal activity against both C. albicans and C. parapsilosis, with a MIC value of 8 m g/mL.
Keywords : Pyridazine derivatives, antibacterial activity, antifungal activity