Synthesis of methyl (E)-2`,4``-thiazachalcones and their N-alkyl derivatives, photochemistry with theoretical calculations and antimicrobial activities

Authors : Asu USTA, Ahmet YAŞAR, Nuran YAYLI

Pages : 621-632

Doi:10.3906/sag-1206-58

View : 14 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of 9 new insert ignore into journalissuearticles values(E);-thiazachalcones insert ignore into journalissuearticles values(1-3);, and their N-alkyl substituted derivatives insert ignore into journalissuearticles values(4-6);, and stereoselective dimerization products insert ignore into journalissuearticles values(7-9); were synthesized, then tested for antimicrobial activity against all test microorganisms except Pseudomonas aeruginosa. The new compounds insert ignore into journalissuearticles values(1-6); without dimerization products insert ignore into journalissuearticles values(7-9); showed good antimicrobial property against Staphylococcus aureus, Listeria monocitogenes, and Enterococcus faecalis. The possible dimerization products of compounds insert ignore into journalissuearticles values(1-3); were calculated theoretically. Experimental and theoretical calculation showed that d-truxinic type dimer is the most stable isomer.
Keywords : Thiazachalcones, N decyl 4 thiazaclaconium bromide, photodimerization, antimicrobial activity