Study of binary complexes of nickel(II), copper(II), and vanadium(V) with acetazolamide in aqueous medium by voltammetry

Authors : İclal BULUT

Pages : 507-520

View : 12 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The voltammetric behaviour of acetazolamide, the systemic carbonic anhydrase inhibitor, in the presence of some metal ions insert ignore into journalissuearticles values(Cuinsert ignore into journalissuearticles values(II);, Niinsert ignore into journalissuearticles values(II);, and Vinsert ignore into journalissuearticles values(V);); were investigated using square-wave and cyclic voltammetry in physiological pH insert ignore into journalissuearticles values(pH 7.4);. Square-wave voltammogram of acetazolamide in the absence of metal ions gave only 1 reduction peak at -1.65 V attributed to a catalytic hydrogen peak. Three reversible peaks at -0.068, -0.262, and -0.434 V were observed for the solutions containing both copperinsert ignore into journalissuearticles values(II); ions and acetazolamide in the SWV. The peak at -0.434 V was attributed to Cuinsert ignore into journalissuearticles values(II);-acetazolamide complex. In the presence of acetazolamide, copper-acetazolamide complex formation was proved by a reversible peak with 2 electron transfers at -0.450 V. Complex formation of an adduct of trioxovanadateinsert ignore into journalissuearticles values(V); with acetazolamide onto dropping mercury electrode was followed by a reduction peak at -0.480 V. Niinsert ignore into journalissuearticles values(II);-acetazolamide complex was observed to reduce at the more positive potential insert ignore into journalissuearticles values(-0.830 V); than that of the hydrated Niinsert ignore into journalissuearticles values(II); ions insert ignore into journalissuearticles values(-1.200 V); implying that acetazolamide is a catalyst for Niinsert ignore into journalissuearticles values(II); reduction at a mercury electrode. The UV-vis spectra of all the acetazolamide complexes were also discussed.
Keywords : Acetazolamide, Copper, Nickel, Vanadium, Binary complexes, Electronic Spectra, Voltammetry