Microwave-Assisted Synthesis of 1,4´-Diazaflavone and N-Alkyl Derivative Pigments with Anti-Microbial Activity

Authors : Nuran YAYLI, Osman ÜÇÜNCÜ, Nurettin YAYLI

Pages : 785-795

View : 14 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :1,4`-Diazaflavone pigment insert ignore into journalissuearticles values(2); was synthesized by a simple environmentally friendly microwave-assisted one-pot method for the cyclization of 2`-amino insert ignore into journalissuearticles values(E);-4``-aza-chalcone insert ignore into journalissuearticles values(1); under solventless conditions using K-10 clay. In addition, 10 new N-alkyl insert ignore into journalissuearticles values(C5-12, 14-15); substituted 1,4` -diazaflavonium bromide pigments insert ignore into journalissuearticles values(3-12); were prepared from compound 2 or directly from compound 1, with corresponding alkyl halides in acetonitrile under reflux. The anti-microbial activity of compounds 1-12 was tested. The N-alkyl substituted 1,4` -diazaflavonium bromides insert ignore into journalissuearticles values(3-12); showed good antimicrobial activity against the gram-positive bacteria tested with minimal bactericidal concentration insert ignore into journalissuearticles values(MBC); values for the reference antibiotic kanamycin. The optimum length of the alkyl chain for better and broader activity was 6-10 carbon atoms in the series of compounds insert ignore into journalissuearticles values(3-12);.
Keywords : Microwave assisted, aza chalcone, 1, 4` diazaflavone, N alkyl 1, 4` diazaflavonium bromide, anti microbial activity, pigment 3 12,