Novel Analogues of 2-Pyrazoline: Synthesis, Characterization, and Antimycobacterial Evaluation

Authors : Ahmet ÖZDEMİR, Gülhan TURAN-ZITOUNI, Zafer Asım KAPLANCIKLI

Pages : 529-538

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Fourteen new 1-[insert ignore into journalissuearticles values(N,N-disubstitutedthiocarbamoylthio);acetyl]- 3-insert ignore into journalissuearticles values(2-thienyl);-5-aryl-2-pyrazoline derivatives were synthesized by reacting 1-insert ignore into journalissuearticles values(chloroacetyl);-3-insert ignore into journalissuearticles values(2-thienyl);-5-aryl-2-pyrazolines and appropriate sodium salts of N,N-disubstituted dithiocarbamoic acids in acetone. The structures of the synthesized compounds were confirmed by UV, IR, 1H-NMR, and FAB+-MS spectral data. The compounds were evaluated for in vitro antimycobacterial activity against Mycobacterium tuberculosis H37Rv using the BACTEC 460 radiometric system and BACTEC 12B medium. The preliminary results showed that all of the tested compounds were inactive against the test organism.
Keywords : 2 Pyrazolines, Sodium salts of N, N disubstituted dithiocarbamoic acids, Antimycobacterial activity