Synthesis and Anticancer Evaluation of Some New Unsymmetrical 3,5-Diaryl-4H-1,2,4-Triazole Derivatives

Authors : Olcay BEKİRCAN, Bahittin KAHVECİ, Murat KÜÇÜK

Pages : 29-40

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of 4-arylidenamino-4H-1,2,4-triazole derivatives insert ignore into journalissuearticles values(3-11); were synthesized from the treatment of 4-amino-4H-1,2,4-triazoles insert ignore into journalissuearticles values(2); with certain aldehydes. Compounds 3-11 were reduced with NaBH4 to afford the corresponding 4-arylmethylenamino-4H-1,2,4-triazoles insert ignore into journalissuearticles values(12-20);. Compounds 1-10 and 12-19 were characterized by elemental analyses and 1H NMR, 13C NMR, IR and UV spectral data. Compounds 11 and 20 were characterized by 1H NMR, 13C NMR, IR and mass spectral data. Compounds 14, 16, 17, and 18 were tested for anticancer activities. Compound 17, chosen for its higher anticancer activity in the preliminary tests with the cancer cell lines of MCF7, NCI-H460, and SF-268, exhibited remarkable anticancer potential in screening tests with 60 human cancer cell lines.
Keywords : 4H 1, 2, 4 Triazoles, 4 Amino 4H 1, 2, 4 triazoles, 4 Arylidenamino 4H 1, 2, 4 triazoles, 4 Arylmethylenamino 4H 1, 2, 4 triazoles, Synthesis, Anticancer activity