Synthesis and Antimicrobial Evaluation of Some New 2-(2-(p-chlorophenyl) benzimidazol-1-yl methyl)-5-substituted amino-[1,3,4]-thiadiazoles

Authors : Gülgün AYHAN KILCIGİL, Canan KUŞ

Pages : 153-162

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Some 2-insert ignore into journalissuearticles values(2-insert ignore into journalissuearticles values(p-chlorophenyl);benzimidazol-1-ylmethyl);-5-substituted amino-[1,3,4]-thiadiazoles were synthesized and their in vitro antimicrobial activities were tested against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Candida albicans and Candida krusei. Compounds 1b and 12b which possess remarkable activity against C. albicans and marginal activity against C. krusei were found to be the most active compounds in this series. Single crystal X-ray diffraction analysis was performed for compound 8b.
Keywords : Benzimidazoles, thiadiazoles, antimicrobial activity, X ray