Atomic Absorption and Spectrophotometeric Determinations of Salicylhydroxamic Acid in Its Pure and Pharmaceutical Dosage Forms

Authors : Alaa-eldin Abdelaziz SALEM

Pages : 383-394

View : 9 | Download : 4

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A new method for the indirect determination of salicylhydroxamic acid insert ignore into journalissuearticles values(SHAM); using atomic absorption spectrometry insert ignore into journalissuearticles values(AAS); was proposed. The method is based on precipitating the ion associate complex of SHAM with [Cu insert ignore into journalissuearticles values(NH3);4]2+. The excess, unreacted, Cu2+ ions were determined using AAS. Another spectrophotometric method based on measuring the absorbance of the formed [Cu insert ignore into journalissuearticles values(NH3);4]-SHAM complex in dioxane was proposed. The green color of the complex formed was measured at 330 nm. The two methods were successfully used for determining SHAM in its pure and pharmaceutical dosage forms. Using AAS, the drug was determined over a concentration range of 3.06 to 30.63 m g/mL with an average relative standard deviation of 1.6 to 2.2% and a recovery of 97.52 to 102.4%. The spectrophotometric method gave a linear concentration range of 1.53 to 18.38 m g/mL with an average relative standard deviation of 1.2 to 1.3% and recovery of 96.73 to 101.31%. The results obtained showed that the methods developed are precise and accurate. They are shown to be suitable for routine SHAM quality control in its pure and pharmaceutical dosage forms.
Keywords : Atomic absorption spectrometry AAS, , spectrophotometry, SHAM, salicylhydroxamic acid, drug analysis, Cu complexes