The Use of Chloranilic Acid for the Spectrophotometric Determination of Three Antihistamines

Authors : K. BASAVAIAH, V.s. CHARAN

Pages : 653-662

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Cyproheptadine hydrochloride insert ignore into journalissuearticles values(CPH);, methdilazine hydrochloride insert ignore into journalissuearticles values(MDH); and promethazine theoclate insert ignore into journalissuearticles values(PMT); were determined in their pure state and in pharmaceutical formulations by a simple spectrophotometric method. The determination was based on the formation of a charge-transfer complex between chloranilic acid as a p-acceptor and the studied drugs as n-donors in an acetonitrile-chloroform mixture. The spectra, various experimental parameters, the stoichiometry and the stability of the complexes formed were investigated. The complexes formed were found to absorb at 520 nm. Beer`s law is obeyed in the concentration ranges 25-125, 20-100 and 25-150 m g ml-1, for CPH, MDH and PMT respectively. The corresponding values of molar absorptivity and Sandell sensitivity are 1.48 x 103, 1.56 x 103 and 1.75 x 103 1 mol-1 cm-1 and 217.39, 212.44 and 284.63 ng cm-2, respectively. The applicability of the method was demonstrated by the determination of the studied drugs in
Keywords : Turk J Chem, 26, 2002, , 653 662 Turk J Chem, vol 26, iss 5