Voltammetry of the Anticancer Drug Mitoxantrone and DNA

Authors : Arzum ERDEM, Mehmet ÖZSÖZ

Pages : 469-476

View : 10 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The interaction of mitoxantrone insert ignore into journalissuearticles values(MTX); with calf thymus double-stranded DNA insert ignore into journalissuearticles values(dsDNA); and calf thymus single-stranded DNA insert ignore into journalissuearticles values(ssDNA); was studied electrochemically by using differential pulse voltammetry insert ignore into journalissuearticles values(DPV); and cyclic voltammetry insert ignore into journalissuearticles values(CV); at a carbon paste electrode insert ignore into journalissuearticles values(CPE);. The changes in the experimental parameters insert ignore into journalissuearticles values(the concentration of MTX, the concentration of DNA and the accumulation time of MTX); were studied by DPV; in addition, the detection limit and the reproducibility were determined. It was observed for the interaction of MTX with dsDNA and ssDNA that the signal of the bare electrode was higher than the signal of the dsDNA modified CPE. The signals in the cyclic voltammograms were found to be decreasing in the following order: bare CPE, ssDNA modified and dsDNA modified CPE.
Keywords : Mitoxantrone, Biosensors, DNA, Voltammetry, Intercalation