Synthesis of novel triazoles bearing 1,2,4-oxadiazole and phenylsulfonyl groups by 1,3-dipolar cycloaddition of some organic azides and their biological activities

Authors : Yaşar DÜRÜST, Hamza KARAKUŞ, Muhsine Zeynep YAVUZ, Ali Akçahan GEPDİREMEN

Pages : 739-755

Doi:10.3906/kim-1309-59

View : 15 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :1,3-Dipolar cycloaddition of 5-azidomethyl-3-p-substituted phenyl-1,2,4-oxadiazoles to phenyl vinyl sulfone and bismaleimide gives rise straightforwardly to 1-insert ignore into journalissuearticles values(insert ignore into journalissuearticles values(3-insert ignore into journalissuearticles values(p-substituted); phenyl-1,2,4-oxadiazol-5-yl);methyl);-4-insert ignore into journalissuearticles values(phenylsul\-fonyl);-4,5-dihydro-1H-1,2,3-triazoles and bisdihydropyrrolo[3,4-d][1,2,3]triazole-4,6insert ignore into journalissuearticles values(3aH,5H);-diones. The structures of the new cycloadducts were elucidated by means of IR, NMR insert ignore into journalissuearticles values(1H, 13C, 2D);, mass spectra, and physical characteristics insert ignore into journalissuearticles values(mp and Rf values);. In addition, anticancer activities of the cycloadducts against MCF-7 cells were also investigated.
Keywords : Azide, 1, 3 dipolar cycloaddition, 1, 2, 4 oxadiazole, 1, 2, 3 triazole, pyrrole, anticancer activity