Synthesis of tertiary propargylic phosphonates by addition of trialkynylaluminum reagents to acyl phosphonates and investigation of their antimicrobial activities

Authors : Mohammad Shakhawoat HOSSAIN, Sıdıka POLAT ÇAKIRdag, Ayşe Betül KARADUMAN

Pages : 880-893

Doi:10.3906/kim-1402-6

View : 16 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A series of propargylic alcohols containing phosphonates was synthesized by addition reactions of tris-insert ignore into journalissuearticles values(propynyl); and tris-insert ignore into journalissuearticles values(phenylethynyl);aluminum reagents to acyl phosphonates in good yields. Aromatic moieties of the acyl phosphonates with electron-withdrawing groups generally resulted in better isolated chemical yield. Selected propargylic phosphonates were tested for antimicrobial activities. Compounds 3a and 3h showed noticeable antifungal activity, especially against molds.
Keywords : Acyl phosphonates, alkynyl organoaluminum, propargylic alcohols, tris phenylethynyl, aluminum, tris propynyl, aluminum, antimicrobial activity