Synthesis and evaluation of novel $N,N`$-disubstituted benzimidazolium bromides salts as antitumor agents

Authors : HASAN KÜÇÜKBAY, AKIN MUMCU, SUAT TEKİN, SÜLEYMAN SANDAL

Pages : 393-401

View : 12 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Novel benzimidazolium bromides salts having insert ignore into journalissuearticles values(4-methoxyphenyl);ethyl, insert ignore into journalissuearticles values(phthalimide-2-yl);methyl, 4-nitro- benzyl, 2-phenylethyl, penthyl, or allyl groups were synthesized and their characterizations were conducted by $^{1}$H and $^{13}$C NMR and IR spectroscopic methods, and microanalysis. In vitro antitumor activities of the novel benzimidazole compounds insert ignore into journalissuearticles values(1-7); were determined by using ovarian insert ignore into journalissuearticles values(A2780); and prostate insert ignore into journalissuearticles values(PC-3); cancer cell lines. Antitumor properties of all compounds were determined by 3-insert ignore into journalissuearticles values(4,5-dimethylthiazol-2-yl);-2,5-diphenyltetrazolium bromide insert ignore into journalissuearticles values(MTT); assay. A time-dependent cell viability assay for the tested benzimidazole compounds was performed and the IC$_{50}$ values of the compounds were calculated after treatment for 24 and 48 h. Our results indicate that the tested benzimidazole compounds show antitumor activity against A2780 and PC-3 cell lines insert ignore into journalissuearticles values(P $
Keywords : Benzimidazole derivatives, antitumor activity, A2780, PC 3