An efficient one-pot, three-component synthesis of 6-cyano-hexahydro-4H -thieno[3’,2’:5,6]pyrimido[1,2-a]quinoline-2-carboxylates and their spiro derivatives from β -enaminones

Authors : Said Ahmed Soliman GHOZLAN, Doaa Mohmed ABDELMONIEM, Amr Mohmed ABDELMONIEM, İsmail Abdelshafy ABDELHAMID

Pages : 434-440

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :A simple and efficient one-pot synthesis of novel thieno[3`,2`:5,6]pyrimido[1,2-a]quinoline-2-carboxylates insert ignore into journalissuearticles values(5a-d); and their spirooxindole derivatives insert ignore into journalissuearticles values(12a-d); was accomplished. Thus, the Michael addition reaction of the cyclic $\beta $-enaminone 3 with the corresponding $\alpha ,\beta $-unsaturated nitrile derivatives 4a-d in refluxing EtOH in the presence of piperidine afforded 5a-d in good yields. On the other hand, spirooxindole derivatives 12a-d were synthesized by the reaction of cyclic $\beta $-enaminone 3 with the corresponding 3-cyanomethylidene-2-oxoindoles 11a-d in refluxing EtOH.
Keywords : Cyclic enaminones, alpha, eta unsaturated nitriles, hexahydroquinolines, multicomponent reaction, spirooxindoles