Electrochemical behavior and voltammetric determination of some nitro-substituted benzamide compounds

Authors : Özlem SAĞLAM, Ferah Cömert ÖNDER, Tuğba GÜNGÖR, Mehmet AY, Yusuf DİLGİN

Pages : 780-793

View : 18 | Download : 4

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Voltammetric behaviors of six nitro-substituted benzamides, which are potential prodrug candidates for nitroreductase-based cancer therapy, were investigated using cyclic voltammetry insert ignore into journalissuearticles values(CV); and differential pulse voltammetry insert ignore into journalissuearticles values(DPV);. The electrochemical behavior of aromatic nitro insert ignore into journalissuearticles values(ArNO$_{2});$ compounds by CV indicates that compounds involve various reduction/oxidation steps including the formation of aromatic nitro radical, nitroso, hydroxylamine, and amine groups. Applicability of the voltammetric determination of these prodrug candidates was studied by recording their DPVs, carried out in mixed media insert ignore into journalissuearticles values(Britton Robinson buffer solution $+$ DMF); at various pH values on a pencil graphite electrode insert ignore into journalissuearticles values(PGE);. Results show that the PGE can offer a disposable, low-cost, and sensitive electrochemical determination method for identifying nitro benzamide compounds. Under the experimental conditions, the PGE had a linear response range from 0.5 to 100 $\mu $M 4-nitro-$N$-insert ignore into journalissuearticles values(2-nitrophenyl);benzamide insert ignore into journalissuearticles values(compound 2);. This voltammetric procedure indicates that nitro-substituted benzamide drugs can be successfully determined in pharmaceutical samples.
Keywords : Voltammetry, pencil graphite electrode, nitro substituted benzamide compounds