Synthesis, spectroscopic studies, and antioxidant activities of novel thio/carbohydrazones and bis-isatin derivatives from terephthalaldehyde

Authors : Halit MUĞLU, Hasan YAKAN, Temel Kan BAKIR

Pages : 237-248

View : 15 | Download : 7

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :New bisinsert ignore into journalissuearticles values(isatins-thio/carbohydrazones); based on Schiff bases were prepared from terephthalaldehyde biscarbohydrazone and 5-substituted isatins in the presence of a drop of sulfuric acid under reflux in ethanol. Terephthalaldehyde bisinsert ignore into journalissuearticles values(thio/carbohydrazone); was synthesized by the reaction of insert ignore into journalissuearticles values(thio);/carbohydrazide and terephthalaldehyde in the presence of a few drops of acetic acid under reflux in ethanol. The structures of these synthesized compounds were determined using IR, 1H NMR, and 13C NMR spectroscopy and elemental analysis. The in vitro antioxidant activity of all the compounds was determined by the 1,1-diphenyl-2-picryl hydrazyl insert ignore into journalissuearticles values(DPPH.); free radical scavenging method. Compound 2 showed the best antioxidant activity.
Keywords : vIsatin, carbohydrazone, Schiff bases, DPPH, spectroscopic techniques