Chemical composition, and antibacterial and antioxidant activities of essential oils from Laggera tomentosa Sch. Bip. ex Oliv. et Hiern (Asteraceae)

Authors : Tokuma GETAHUN, Vinit SHARMA, Deepak KUMAR, Neeraj GUPTA

Pages : 1539-1548

View : 13 | Download : 4

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Laggera tomentosa Sch. Bip. ex Oliv. et Hiern insert ignore into journalissuearticles values(Asteraceae);, an endemic Ethiopian medicinal plant, is traditionally used to treat various ailments. Previously, the chemical constituents of the essential oil insert ignore into journalissuearticles values(EO); of its leaves and inflorescence were documented. However, no data about the chemical compositions of other parts of the EOs of the plant have been reported to date. Moreover, there are no previous biological activity reports on any parts of the EOs of this plant. Thus, in this study, the EOs were isolated from the stem bark and roots of this plant by hydrodistillation and analyzed using gas chromatography-mass spectrometry to identify their components. In addition, antibacterial potentials of the oils were evaluated using the disc diffusion and minimal inhibitory concentration insert ignore into journalissuearticles values(MIC); methods. 2,2-diphenyl-1-picrylhydrazyl insert ignore into journalissuearticles values(DPPH); and hydrogen peroxide methods were also employed to assess their antioxidant properties. Oxygenated monoterpenes insert ignore into journalissuearticles values(71.82% and 77.51%);, of which 2,5-dimethoxy-p-cymene insert ignore into journalissuearticles values(57.28% and 64.76%); and thymol methyl ether insert ignore into journalissuearticles values(9.51% and 8.93%); were identified as major components in the EOs of stem bark and roots of L. tomentosa and the oils, were the most potent in the DPPH insert ignore into journalissuearticles values(IC50 , 0.33 1.10 and 0.39 is 0.97 mg/mL); assay, respectively. Moreover, the Ms demonstrated appreciable activity towards the gram+ insert ignore into journalissuearticles values(S. aureus and B. cereus); bacteria. Among thew oils, the oil of the stem bark showed the greatest activity to the gram+ insert ignore into journalissuearticles values(MIC 0.625 mg/mL); bacteria. Therefore, the overall results suggested that the EOs of L. tomentosa may be a promising prospect for pharmaceutical, food, and other industrial applications.
Keywords : Laggera tomentosa, essential oils, 2, 5 dimethoxy p cymene, thymol methyl ether, antibacterial and antioxidant activities