Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery

Authors : Nasrin ALİASGHARLOU, Farzin ASGHARİ SANA, Saba KHOSHBAKHT, Pezhman ZOLFAGHARİ, Hamed CHARKHİAN

Pages : 1723-1732

View : 15 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In this study, boric acid insert ignore into journalissuearticles values(BA); is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose insert ignore into journalissuearticles values(EC); and polyvinyl alcohol insert ignore into journalissuearticles values(PVA);, for topical drug delivery applications. The developed films are characterized by FIT R spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and transparent, except for the BA-modified EC sample. The initial cumulative release for erythromycin insert ignore into journalissuearticles values(EM); is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at 25 degrees C. Further, the developed formulations are stable for 75 days. Also, the antibacterial activity of the developed formulations is investigated against S. aureus insert ignore into journalissuearticles values(ATCC insert ignore into journalissuearticles values(R); 25923 insert ignore into journalissuearticles values(TM); and ATCC insert ignore into journalissuearticles values(R); 29213 insert ignore into journalissuearticles values(TM););. The obtained data confirm that the application of BA as the crosslinking agent extends the release of EM from EC and PVA polymeric films. The findings of this study suggest that BA-crosslinked EC and PVA films are promising carriers for controlled topical drug delivery applications.
Keywords : Drug delivery system, polymeric film, polyvinyl alcohol, ethyl cellulose, boric acid, erythromycin