Preparation, structure elucidation, and antioxidant activity of new bis(thiosemicarbazone) derivatives

Authors : Hasan YAKAN

Pages : 1085-1099

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Schiff-base-bearing new bisinsert ignore into journalissuearticles values(thiosemicarbazone); derivatives were prepared from terephthalaldehyde and various thiosemicarbazides. FT-IR, H-1 NMR, C-13 NMR, and UV-Vis spectroscopic methods and elemental analysis were used to elucidate the identification of the synthesized molecules. The in vitro antioxidant activity of the synthesized compounds was analysed with the 1,1-diphenyl-2-picryl hydrazyl free-radical-trapping process. The synthesized compounds exhibited lower antioxidant activity than the standard ascorbic acid. IC50 values of the synthesized molecules measured from 3.81 +/- 0.01 to 29.05 +/- 0.11 mu M. Among the synthesized compounds, compound 3 had the best antioxidant activity. Moreover, this study explained the structure-activity relationship of the synthesized molecules with different substituents in radical trapping reactions.
Keywords : Thiosemicarbazides, Schiff bases, DPPH, structureactivity relationship, spectroscopic methods