The protective and therapeutic effect of phenoxy-2-methyl-2-propionic acid on experimental fatty liver in rats

Authors : Ümmügülsüm GÜMÜŞ, Gülbin ŞENNAZLI, Utku BAKIREL

Pages : 653-658

Doi:10.3906/tar-1210-21

View : 16 | Download : 8

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In this study, the potential protective and therapeutic effect of phenoxy-2-methyl-2-propionic acid insert ignore into journalissuearticles values(PMPA); was investigated in rats with experimental hepatic steatosis induced by a carbon tetrachloride and paraffin liquid mixture insert ignore into journalissuearticles values(1:1);. Forty Wistar albino rats were allocated to 4 groups with 10 rats in each. Group 1 was administered a saline solution; group 2 was administered the carbon tetrachloride and paraffin liquid mixture; group 3 was administered the carbon tetrachloride and paraffin liquid mixture and PMPA for 7 days; and in group 4, hepatic steatosis was created with the carbon tetrachloride and paraffin liquid mixture during the first 7 days, after which the rats were administered only PMPA during the last 7 days. All injections were done intraperitoneally. Blood samples were obtained from all rats and livers were extirpated before euthanasia. Blood parameters were found to be significantly different between the groups insert ignore into journalissuearticles values(P < 0.05);. On histopathologic examination, grade 1 hepatic steatosis was observed in group 1; grade 3 hepatic steatosis and grade 2 portal fibrosis were observed in group 2; grade 2 hepatic fibrosis and grade 1 portal fibrosis were observed in group 3; and grade 1 hepatic steatosis was observed in group 4. Hepatic fibrosis was induced in the rats using a carbon tetrachloride and paraffin liquid mixture. Results indicated that PMPA has a limited protective effect and a superior therapeutic effect on hepatic steatosis.
Keywords : Key words Hepatic steatosis, rat, phenoxy 2 methyl 2 propionic acid, histopathologic examination, blood parameters