Immune system dysfunction in broiler chickens experimentally inoculated with fowl adenovirus serotype-4 associated with inclusion body hepatitis hydropericardium syndrome

Authors : İftikhar HUSSAIN, Muhammad Shahid MAHMOOD, Muhammad İmran ARSHAD, Masood AKHTAR, Fazal MAHMOOD, Azhar RAFIQUE

Pages : 223-230

Doi:10.3906/sag-1207-32

View : 13 | Download : 4

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Inclusion body hepatitis-hydropericardium syndrome insert ignore into journalissuearticles values(IBH-HPS); in broilers is caused by an adenovirus, here referred to as inclusion body hepatitis-hydropericardium syndrome virus insert ignore into journalissuearticles values(IBH-HPSV);. This study describes the immune status of broiler chickens experimentally inoculated with an isolate of fowl adenovirus-4 serotype-1, involved in IBH-HPS in various trials. When compared with the unchallenged controls, IBH-HPSV-inoculated broilers had significantly higher atrophy of the bursa of Fabricius insert ignore into journalissuearticles values(BF); by up to 2-fold, as well as of the thymus insert ignore into journalissuearticles values(up to 9-fold); and spleen insert ignore into journalissuearticles values(up to 1.5-fold); insert ignore into journalissuearticles values(P < 0.05);, with up to 60% mortality. Upon challenge with sheep red blood cells insert ignore into journalissuearticles values(SRBCs);, IBH-HPSV-inoculated birds had from 2- to 3-log lower anti-SRBC antibody titers than the control. Response to phytohemagglutinin-P insert ignore into journalissuearticles values(PHA-P); was significantly reduced in IBH-HPSV-inoculated birds insert ignore into journalissuearticles values(P < 0.05); as compared to the control. Results of the studies revealed that the immune status of broilers is compromised significantly during IBH-HPSV infection in terms of lymphoid organ integrity, humoral, and cell-mediated immune responses, respectively. These findings suggest that immune dysfunction could be a contributing factor in the increased mortality of birds affected by IBH-HPS, which renders the birds immunosuppressed for the rest of their lives.
Keywords : Key words Immune system dysfunction, inclusion body hepatitis hydropericardium syndrome, broilers, immune response, sheep red blood cells, phytohemagglutinin P