The pharmacokinetics of cefepime in goats following single-dose i.v. and i.m. administration

Authors : Shahid PRAWEZ, Rajinder RAINA, Dimitritchka DIMITROVA, Nrip Kishore PANKAJ

Pages : 427-431

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The pharmacokinetics of cefepime was studied in 5 goats following i.v. and i.m. administration of 10 mg/kg of body weight. Following i.v. administration, the cefepime plasma concentration-time curves were best fitted in a one-compartment open model. The elimination half-life insert ignore into journalissuearticles values(t1/2b);, area under curve insert ignore into journalissuearticles values(AUC0/rightarrow/infinity);, and total body clearance insert ignore into journalissuearticles values(ClB); were 1.86 ± 0.54 h, 181.58 ± 80.52 mg.h/mL, and 1.10 ± 0.54 mL/min/kg, respectively. Following i.m. administration, pharmacokinetic parameters were analyzed using statistical moment theory insert ignore into journalissuearticles values(SMT);. The drug was absorbed rapidly, with an absorption half-life insert ignore into journalissuearticles values(t1/2abs); of 0.77 ± 0.34 h. The peak plasma concentration insert ignore into journalissuearticles values(Cmax); of 49.32 ± 10.33 mg/mL was attained after insert ignore into journalissuearticles values(Tmax); 0.80 ± 0.11 h, with an elimination half-life insert ignore into journalissuearticles values(t1/2b); of 1.65 ± 0.38 h. The systemic bioavailability insert ignore into journalissuearticles values(F); of cefepime in the goats after i.m. administration was 86.45 ± 17.39% and in vitro plasma protein binding was 7.45 ± 4.46%. The dosage regime was estimated via the PK-PD relationship, considering the t>MIC value. The results suggest that cefepime was a potential bactericidal agent for more than 7 h by both administration routes, and that it might be very useful in the treatment of various infections in goats at 10 mg/kg of body weight administered i.v. or i.m. with 10 h as the dosage interval.
Keywords : Turk J Vet Anim Sci 2010, 34 427 431 Turk J Vet Anim Sci, vol 34, iss 5