Nuclear morphometry in relation to tumor grade in canine spontaneous cutaneous squamous cell carcinomas

Authors : Radostin SIMEONOV

Pages : 439-442

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Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :In a retrospective study on cytological specimens from 17 dogs with histologically confirmed cutaneous squamous cell carcinoma, the morphometric variables were studied and compared to tumors` nuclear grade. The morphometric parameters evaluated in this study were mean nuclear area insert ignore into journalissuearticles values(MNA, µm2);, mean nuclear perimeter insert ignore into journalissuearticles values(MNP, µm);, mean nuclear diameter insert ignore into journalissuearticles values(D mean, µm);, minimum nuclear diameter insert ignore into journalissuearticles values(D min, µm);, and maximum nuclear diameter insert ignore into journalissuearticles values(D max, µm);. Associations between MNA, MNP, D mean, D min, and D max and tumors` grade were assessed using the ANOVA/LSD test insert ignore into journalissuearticles values(Statistica 6.0, StatSoft, USA); at a level of significance of P < 0.05. The result indicated an increase in the mean values of the nuclear parameters with increasing tumor grade. In the cases examined, significant differences in MNA, MNP, and D mean occurred between tumors in all grades. Besides, no significant differences in D max insert ignore into journalissuearticles values(between grade I-II and II-III); and D min insert ignore into journalissuearticles values(grade II-III); were found. In conclusion, nuclear morphometry could be used as an additional tool for differentiating nuclear grade in canine cutaneous squamous cell carcinomas.
Keywords : Key words Image analysis, nuclear morphometry, tumor grade, canine cutaneous squamous cell carcinomas