Single Dose Pharmacokinetics of Cefepime after Intravenous and Intramuscular Administration in Goats

Authors : Kalpesh PATANI, Urvesh PATEL, Shailesh BHAVSAR, Aswin THAKER

Pages : 159-162

View : 14 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Pharmacokinetics of cefepime was determined following single dose intravenous insert ignore into journalissuearticles values(IV); and intramuscular insert ignore into journalissuearticles values(IM); administration at the rate of 10 mg/kg body weight in a crossover design with an interval of 21 days between IV and IM injections. The experiment was done on 6 healthy young female Surati goats insert ignore into journalissuearticles values(4-6 months of age);. All animals were randomly allocated to receive either IV or IM injection of the drug. Blood samples were collected at various time intervals. Cefepime concentration in serum was determined by high performance liquid chromatography insert ignore into journalissuearticles values(HPLC);. The serum drug concentration-time profile was characteristic of a 2- and 1-compartment open model following IV and IM administration, respectively. Following single dose IV administration, the drug was rapidly distributed insert ignore into journalissuearticles values(t1/2a: 0.20 ± 0.02 h; Vd insert ignore into journalissuearticles values(area);; 0.52 ± 0.04 l/kg); and slowly eliminated insert ignore into journalissuearticles values(t1/2b: 2.71 ± 0.08 h); from the body. Following IM administration, the drug was rapidly absorbed insert ignore into journalissuearticles values(t1/2ka: 0.16 ± 0.01 h); and slowly eliminated insert ignore into journalissuearticles values(t1/2b : 4.89 ± 0.24 h); from body. The bioavailability of cefepime was 69 ± 6.0% following IM injection. Based on observed serum drug concentration, cefepime can be used intramuscularly at the dose rate of 10 mg/kg every 12 h in goats.
Keywords : Pharmacokinetics, cefepime, goats, intravenous, intramuscular