Inhibition Effect of Some Chemical Anesthetics and Hypothermia on the Activity of Glucose 6-phosphate Dehydrogenase From Rainbow Trout (Oncorhynchus mykiss) Erythrocytes In Vivo

Authors : Abdulkadir ÇİLTAŞ, Orhan ERDOĞAN, Olcay HİSAR, Esat Mahmut KOCAMAN

Pages : 813-817

View : 10 | Download : 4

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Many chemical anesthetics and drugs have been used in fish stripping, surgery and transportation, but their undesirable side effects on the body metabolism during treatment are not usually taken into consideration. In this study, we investigated the inhibition effect of some chemical anesthetics, such as Tranquil and tricaine methanesulfonate insert ignore into journalissuearticles values(MS-222);, and hypothermia on glucose 6-phosphate dehydrogenase insert ignore into journalissuearticles values(G6PDH); activity. The control, initial, 1 h and 4 h values were 41.334 ± 3.190 EU insert ignore into journalissuearticles values(g Hb);-1, 34.586 ± 5.086 EU insert ignore into journalissuearticles values(g Hb);-1, 40.768 ± 3.430 EU insert ignore into journalissuearticles values(g Hb);-1 and 41.957 ± 3.157 EU insert ignore into journalissuearticles values(g Hb);-1, respectively, in hypothermia. These values were 39.470 ± 2.250 EU insert ignore into journalissuearticles values(g Hb);-1, 35.807 ± 2.000 EU insert ignore into journalissuearticles values(g Hb);-1, 32.756 ± 7.822 EU insert ignore into journalissuearticles values(g Hb);-1 and 34.882 ± 3.452 EU insert ignore into journalissuearticles values(g Hb);-1 with Tranquil and 52.910 ± 2.490 EU insert ignore into journalissuearticles values(g Hb);-1, 27.044 ± 2.750 EU insert ignore into journalissuearticles values(g Hb);-1, 39.901 ± 4.477 EU insert ignore into journalissuearticles values(g Hb);-1 and 42.629 ± 2.593 EU insert ignore into journalissuearticles values(g Hb);-1 with MS-222, respectively. Hypothermia, Tranquil and MS-222 showed inhibition effects on G6PDH activity. The inhibition effects of hypothermia and Tranquil were not statistically significant insert ignore into journalissuearticles values(P > 0.05);, but MS-222 caused statistically quite high inhibition initially insert ignore into journalissuearticles values(P < 0.01);. The inhibition effect of MS-222 diminished 1 h and 4 h after treatment insert ignore into journalissuearticles values(P < 0.05);.
Keywords : Oncorhynchus mykiss, anesthetics, inhibition, G6PDH