The Effect of Long-Term Supplemental Dietary Cadmium on Lipid Peroxidation and the Antioxidant System in the Liver and Kidneys of Rabbits

Authors : Ebru BEYTUT

Pages : 1055-1060

View : 9 | Download : 4

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :We investigated the effects of chronic exposure to dietary cadmium insert ignore into journalissuearticles values(Cd); on the levels of lipid peroxidation insert ignore into journalissuearticles values(LPO); and reduced glutathione insert ignore into journalissuearticles values(GSH); associated with activities of glutathione peroxidase insert ignore into journalissuearticles values(GSH-Px); and the catalase insert ignore into journalissuearticles values(CAT); enzyme in the liver and kidneys of rabbits. Twenty 10-month-old clinically healthy New Zealand white rabbits insert ignore into journalissuearticles values(10/group); of 3545 ± 250 g average body weight were used. The control group was allowed to take food and tap water ad libitum, while the experimental group was given tap water containing 200 ppm CdCl2/L for 28 weeks. Lipid peroxidation contents increased significantly in the liver insert ignore into journalissuearticles values(p < 0.001); and kidneys insert ignore into journalissuearticles values(p < 0.005); of Cd-treated rabbits. Glutathione levels decreased significantly in both the liver insert ignore into journalissuearticles values(p < 0.001); and the kidneys insert ignore into journalissuearticles values(p < 0.005); of the experimental group. Cadmium treatment caused a significant decrease in the activities of GSH-Px and CAT in the liver insert ignore into journalissuearticles values(p < 0.001, p < 0.01); and kidneys insert ignore into journalissuearticles values(p < 0.005, p < 0.1); of the rabbits. These results indicated that a Cd-induced increase in LPO was associated with reductions in GSH-Px and CAT enzyme activities, and in GSH levels in the liver and kidneys of rabbits.
Keywords : Cadmium, Lipid peroxidation, Glutathione peroxidase, Catalase, Glutathione, Rabbit