Lipid Peroxidation, Antioxidant Enzymes and Pyruvate Kinase Activity in Rats With Carbon Tetrachloride-Induced Cirrhosis

Authors : Seval YILMAZ

Pages : 25-28

View : 9 | Download : 4

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Changes in the level of malondialdehyde insert ignore into journalissuearticles values(MDA, a degradative product of lipid peroxidation); and in the antioxidant defense system in rats with carbon tetrachloride-induced liver cirrhosis were studied, in order to determine whether there is any relation between these parameters and the disease. Liver cirrhosis was induced in Wistar-Albino rats by carbon tetrachloride insert ignore into journalissuearticles values(0.15 gr/100 gr body weight); which was injected subcutanously three times a week for six weeks. In the liver, the level of tissue malondialdehyde was analysed according to Yagi`s method; and glutathione peroxidase, glucose-6-phosphate dehydrogenase, pyruvate kinase activities according to Beutler`s method. The level of liver malondialdehyde in the group with cirrhosis was significantly higher than in the control group insert ignore into journalissuearticles values(p
Keywords : Cirrhosis, lipid peroxidation, glutathione peroxidase, glucose 6 phosphate dehydrogenase, pyruvate kinase