Cannabinoid receptor type 2 agonist JWH-133 deteriorates the liver toxicity induced by cypermethrin

Authors : Hidayet TUTUN, Emine BAYDAN

Pages : 211-221

View : 9 | Download : 4

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :Cannabinoid receptor 2 insert ignore into journalissuearticles values(CB2); has a role in the pathology of some liver diseases. Cypermethrin insert ignore into journalissuearticles values(CYP); is a synthetic pyrethroid insecticide used commonly for the control of pests and vectors, and for protection of foodstuffs. In this study, the involvement of CB2 in CYP-induced liver damage in rats was investigated. CYP was applied to rats orally at a dose of 125 mg/kg bw per day for 14 days. CB2 agonist JWH-133 was administered by intraperitoneal injection at a dose of 3 mg/kg bw per day for the last 4 days of CYP toxicity. JWH-133 deteriorated the liver damage induced by CYP. JWH-133 increased serum hepatic enzyme activities insert ignore into journalissuearticles values(aspartate aminotransferase, alanine aminotransferase); in rats given CYP. However, it decreased lipid peroxidation. There were no differences in the levels of hepatic CB2 mRNA among the groups. CB2 receptors were expressed in a small amount in normal liver tissue. In contrast, the expression levels of CB2 in CYP-treated rats were increased in fibrocyte/fibroblast, bile duct epithelial cells, Kupffer cells, and mast cells. In conclusion, CB2 was upregulated in the liver exposed to CYP, predominantly in hepatic fibrogenic cells. JWH-133 enhanced the CYP-induced liver damage by receptor mediated and/or nonreceptor-mediated mechanisms. CB2 antagonists may reduce the damage. The results of the study show that CB2 might be involved in the physiopathological process of CYP-induced liver injury and justify the need for further study.
Keywords : Cannabinoid receptor type 2, CB2, cypermethrin, JWH 133, liver, rat