Effect of epidural dexmedetomidine with or without local anesthetics on pain score and serum IL-6 levels in dogs undergoing elective ovariohysterectomy

Authors : Mudasir Ahmad SHAH, , Prakash KINJAVDEKAR, Amarpal Deepti SHARMA, Abhijit Motiram PAWDE, Abu Rafee MALIK, Abas Rashid BHAT

Pages : 14-17

View : 10 | Download : 4

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :  To evaluate the postoperative analgesic effects of epidural dexmedetomidine with or without local anesthetics, prospective randomized double-blinded clinical trials were performed with 24 healthy client-owned mixed-breed adult dogs with an average weight of 18.1 ± 2.4 kg allotted equally insert ignore into journalissuearticles values(n = 6); to four groups: A, B, C, and D. All animals were premedicated intramuscularly with atropine insert ignore into journalissuearticles values(0.04 mg/kg); and after 5 min by intravenous midazolam insert ignore into journalissuearticles values(0.7 mg/kg);. After 10 min of premedication, in group A dexmedetomidine insert ignore into journalissuearticles values(7 µg/kg); and in groups B, C, and D, in addition to dexmedetomidine insert ignore into journalissuearticles values(7 µg/kg);, lidocaine insert ignore into journalissuearticles values(4.4 mg/kg);, bupivacaine insert ignore into journalissuearticles values(2 mg/kg);, and ropivacaine insert ignore into journalissuearticles values(2 mg/kg);, respectively, were administered to the lumbosacral epidural space, respectively. Anesthesia was maintained with 1% propofol as and when needed. Postoperative analgesia was assessed subjectively using the University of Melbourne Pain Scale insert ignore into journalissuearticles values(UMPS); at 1, 2, 4, and 24 h postoperatively and objectively by measuring the circulating levels of interleukin-6 insert ignore into journalissuearticles values(IL-6); at 0 insert ignore into journalissuearticles values(baseline);, 1, 2, 4, and 24 h postoperatively. Overall, UMPS scores were lower in groups B, C, and D at all time points compared to group A. Serum IL-6 levels showed a nonsignificant decrease in groups B and C with a nonsignificant increase in group D at different intervals as compared to baseline. However, a significantly higher serum IL-6 level was recorded at 4 h in group A as compared to the other three groups. It was concluded that epidural dexmedetomidine in combination with lidocaine, bupivacaine, or ropivacaine at the doses studied provides better postoperative analgesia than dexmedetomidine alone in dogs undergoing elective ovariohysterectomy. However, the dexmedetomidine/ropivacaine combination revealed comparatively lower postoperative analgesia than dexmedetomidine/lidocaine and dexmedetomidine/bupivacaine combinations.
Keywords : Elective ovariohysterectomy, dexmedetomidine, local anesthetics, serum interleukin 6, University of Melbourne Pain Scale, dogs