Thromboelastographic evaluation of hemostatic function in dogs with dilated cardiomyopathy

Authors : Zeki YILMAZ, Meriç KOCATÜRK, Oya ERALP İNAN, Pınar LEVENT

Pages : 372-379

View : 15 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :  This study aimed to evaluate the hemostatic function by thromboelastography insert ignore into journalissuearticles values(TEG); and determine if there was an association between the changes in hemostatic parameters and serum cardiac troponin I insert ignore into journalissuearticles values(cTnI); in dogs with dilated cardiomyopathy insert ignore into journalissuearticles values(DCM);. DCM was diagnosed by echocardiography in 19 dogs. Ten healthy dogs were selected as controls. Myocardial injury was confirmed by increased serum cTnI levels. Coagulation was assessed by TEG evaluating clot kinetics insert ignore into journalissuearticles values(reaction time [R] and kinetic time [K]);, clot strengthening insert ignore into journalissuearticles values(alpha [α] angle and G value);, platelet function insert ignore into journalissuearticles values(maximum amplitude [MA] and coagulation-index [CI]);, clot stability insert ignore into journalissuearticles values(LY30, the percentage of lysis 30 min after MA);, and global clotting times insert ignore into journalissuearticles values(activated partial thromboplastin time [aPTT] and prothrombin time [PT]);. Dogs with DCM had higher R and K times but lower MA, α-angle, G, and CI compared to controls insert ignore into journalissuearticles values(P < 0.05);. LY30 and PT did not statistically differ between groups, but the aPTT in dogs with DCM was higher than that of the controls. Serum cTnI insert ignore into journalissuearticles values(median [range], ng/mL); was higher in dogs with DCM insert ignore into journalissuearticles values(0.25 [0.13-3.1]); than in healthy dogs insert ignore into journalissuearticles values(0.03 [0.01-0.06]);. There was no statistical relation between cTnI and coagulation parameters. This study showed that alterations of the coagulation status in dogs with DCM could develop independently of serum cTnI elevations.
Keywords : Dilated cardiomyopathy, thromboelastography, hemostasis, cardiac troponin I, dog