Proliferation effects of phenylboronic acid and boric acid on canine peripheral blood mononuclear cells

Authors : Uçkun Sait UÇAN, Zafer SAYIN

Pages : 229-234

View : 9 | Download : 5

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The effects of phenylboronic acid insert ignore into journalissuearticles values(PBA); and boric acid insert ignore into journalissuearticles values(BA); on the proliferation of canine peripheral blood mononuclear cells insert ignore into journalissuearticles values(PBMCs); were investigated. Treatment of PBMCs from mixed breed dogs with PBA or BA insert ignore into journalissuearticles values(0.05 µg/mL); alone elicited blastogenic responses of 0.478 ± 0.438 and 0.499 ± 0.366, respectively. We observed an additive effect on proliferation when purebred Kangal PBMCs were cultured in a combination of BA insert ignore into journalissuearticles values(0.001 µg/mL); and the mitogenic lectin concanavalin A insert ignore into journalissuearticles values(1 µg/mL);. However, the effects were not statistically significant. We detected varied IL-2 and IL-4 secretion in response to stimulation with boron-containing compounds. Our findings suggest that PBA induces canine PBMC proliferation, albeit less potently than lectins. However, boronic acid compounds may still prove beneficial as adjuvants to elicit cell proliferation and boost canine immune responses.
Keywords : Boric acid, canine, mitogen, phenylboronic acid, proliferation