Subarachnoid transplantation of autologous neurogenically induced bone marrow derived mesenchymal stem cells for the treatment of fibrocartilaginous embolic myelopathy in two dogs

Authors : Pinar CAN, Ömer BEŞALTI, Eylül AKPINAR, Zeynep AKTAŞ, Ayşe Eser ELÇİN, Yaşar Murat ELÇİN

Pages : 120-123

View : 15 | Download : 3

Publication Date : 0000-00-00

Article Type : Research Paper

Abstract :The objective of this study was to investigate the effects of autologous neurogenically induced bone marrow-derived mesenchymal stem cells insert ignore into journalissuearticles values(NIBM-MSCs); in two dogs suspected to have fibrocartilaginous embolic myelopathy insert ignore into journalissuearticles values(FCEM);. Both dogs were paraplegic without deep pain perception insert ignore into journalissuearticles values(DPP); and tentatively diagnosed by MRI. Autologous NIBM-MSCs insert ignore into journalissuearticles values(5 × 106); were transplanted into the lumbar subarachnoid space two times with a 21-day interval for each patient. Based on a 21-month follow-up of the treated animals, the transplantation of NIBM-MSCs seems to be promising in subjects with FCEM lacking DPP.
Keywords : Dog, subarachnoid transplantation, mesenchymal stem cells