Renal Involvement and Outcomes in Patients Hospitalized with COVID-19 Infection in A Tertiary Hospital

Authors : Sahana K.S., Santhosh BH PAİ, Rony GEORGE

Pages : 117-123

Doi:10.46310/tjim.1209442

View : 11 | Download : 8

Publication Date : 2023-04-29

Article Type : Research Paper

Abstract :Background Kidney involvement is seen frequently in COVID-19 patients and is essential to the prognosis. This study is undertaken to describe the clinical presentation of renal involvement in COVID-19 patients concerning acute kidney injury insert ignore into journalissuearticles values(AKI);, chronic kidney disease insert ignore into journalissuearticles values(CKD);, and urinary abnormalities and to correlate with the severity of COVID-19 illness and its outcome. Material and Methods A retrospective cross-sectional study reviewed the medical records of patients admitted with COVID-19 infection who had pre-existing renal conditions or renal manifestations in the form of deranged renal function tests or abnormal urinary findings. All the relevant clinical and laboratory parameters, including the treatment details and outcome, were noted, and statistical analysis was done. Results A total of 72 out of 1,544 patients satisfied the inclusion criteria. Hypertension insert ignore into journalissuearticles values(72%); and Diabetes insert ignore into journalissuearticles values(62%); were the commonest co-morbidities noted. CKD was seen in 51 insert ignore into journalissuearticles values(70%); patients, and 21 patients insert ignore into journalissuearticles values(29%); were on maintenance dialysis. 39 insert ignore into journalissuearticles values(76%); patients with CKD were diagnosed with severe COVID-19, 25 insert ignore into journalissuearticles values(49%); of the patients developed acute worsening of CKD, and 45% had mortality. AKI was seen in 19 patients insert ignore into journalissuearticles values(26%);. Urinary abnormality was seen in 34 insert ignore into journalissuearticles values(47%); patients, out of which 27 insert ignore into journalissuearticles values(37%); had proteinuria of more than 1+. Haematuria was seen in 27 insert ignore into journalissuearticles values(37.5%); patients, of which 12insert ignore into journalissuearticles values(17%); had gross haematuria. Dialysis was required in 24 patients insert ignore into journalissuearticles values(33%); additionally. Mechanical ventilation was required in 32insert ignore into journalissuearticles values(44%); patients, and inotropes in 41insert ignore into journalissuearticles values(56%);. 21 insert ignore into journalissuearticles values(29%); patients developed acute respiratory distress syndrome, 39 insert ignore into journalissuearticles values(54%); had sepsis, with six patients developing multiorgan dysfunction syndrome. 62.5% of patients had mortality. The presence of other comorbid conditions, thrombocytopenia, coagulopathy, abnormality in arterial blood gases, and usage of inotropes were found to be significantly associated with adverse outcomes. Conclusions Most cases had severe renal system involvement, with an AKI prevalence rate of 1.2% and a case-specific mortality rate of 62.5%.
Keywords : COVID 19, Renal involvement, Acute kidney injury