Implications of homocysteine levels and carotid intima-media thickness in Indian stroke patients

Authors : Vatsal Navin JAİN, Priyanka RANA, Kshitij Arun BHOGE, Mohit Vijay ROJEKAR

Pages : 176-184

Doi:10.46310/tjim.1248356

View : 61 | Download : 97

Publication Date : 2023-07-29

Article Type : Research Paper

Abstract :Background The study aimed to evaluate the role of homocysteine insert ignore into journalissuearticles values(HCY); in modulating various stroke parameters. The primary objective was to study the correlation of HCY levels with carotid intima-media thickness insert ignore into journalissuearticles values(IMT); in stroke patients and investigate if HCY levels had any predictive value for the National Institutes of Health Stroke Scale insert ignore into journalissuearticles values(NIHSS); score. Material and Methods Seventy-eight patients of magnetic resonance imaging or computed tomography scans-confirmed acute ischaemic stroke were recruited for this study, and the NIHSS score was evaluated upon admission. Fasting blood samples were tested for serum HCY, fasting blood glucose insert ignore into journalissuearticles values(FBG); and lipid profile. Ultrasonography of the neck ascertained IMT of common carotid artery insert ignore into journalissuearticles values(CCA); and internal carotid artery insert ignore into journalissuearticles values(ICA);. Results The mean age of male and female subjects was 57.88±13.97 and 59.16±13.62 years, respectively. 71.93% of stroke patients were hyperhomocysteinemic insert ignore into journalissuearticles values(HHcyc);, and 24.36% were hyperlipidemic. Patients with NIHSS ≥5 had higher LDL cholesterol than those with NIHSS <5. Positive correlations were found between FBG and CCA IMT and triglyceride and NIHSS. HCY cut off of ≥15 μmol/L had 91.7% sensitivity and 66.7% specificity for predicting NIHSS ≥15. HHcyc state was associated with increased ICA IMT. HHcyc state was best predicted by ICA IMT and HCY positively correlated with ICA IMT. Conclusions HHcyc state holds a good predictive value for the severity of stroke. We also concluded that ICA IMT measurement may reduce the need for a HCY test as it predicts higher HCY levels, reducing the burden on resources. We suggest that evaluating HCY and ICA IMT should be part of the standard cerebrovascular accident management protocol.
Keywords : carotid intima media thickness, homocysteine, stroke