The role of plasma atherogenic index in patients with NAFLD

Authors : Ali KIRIK, Hacer ŞEN

Pages : 185-190

Doi:10.46310/tjim.1256322

View : 74 | Download : 70

Publication Date : 2023-07-29

Article Type : Research Paper

Abstract :Background Plasma atherogenic index insert ignore into journalissuearticles values(PAI); is a novel index investigated in recent years related to cardiovascular disease and atherosclerosis. The role of PAI is not clear in non-alcoholic fatty liver disease insert ignore into journalissuearticles values(NAFLD);. This study aimed to examine the role of PAI in patients with NAFLD and its relationship with metabolic components. Material and Methods This study was designed as a retrospective study, and the patients\` files admitted to the Internal Medicine unit were retrospectively scanned. Within the scope of the study, demographic and laboratory data of the groups with and without NAFLD were compared. Results A total of 234 patients were evaluated, 159 of which were NAFLD insert ignore into journalissuearticles values(age: 39.52 ± 10.38 years); and 75 controls insert ignore into journalissuearticles values(age: 38.07 ± 12.11 years); insert ignore into journalissuearticles values(p = 0.374);. PAI level was statistically significantly higher in the NAFLD group compared to the control group insert ignore into journalissuearticles values(p = 0.006);. In the whole group correlation analysis, PAI level and body mass index insert ignore into journalissuearticles values(p < 0.001, r = 0.363);, waist circumference insert ignore into journalissuearticles values(p < 0.001, r = 0.366);, systolic blood pressure insert ignore into journalissuearticles values(p < 0.001, r = 0.333);, diastolic blood pressure insert ignore into journalissuearticles values(p = 0.001, r = 0.210);, ALT insert ignore into journalissuearticles values(p < 0.001, r = 0.312);, AST insert ignore into journalissuearticles values(p = 0.005, r = 0.182);, fasting plasma glucose insert ignore into journalissuearticles values(p = 0.017, r = 0.157); and insulin resistance insert ignore into journalissuearticles values(p < 0.001, r = 0.302); values were positively correlated. Conclusions PAI level was higher in patients with NAFLD; this index was associated with other metabolic components, especially insulin resistance. This indicates that the PAI level may be associated with clinical progression in the pathogenesis and course of the disease.
Keywords : Non alcoholic fatty liver disease, plasma atherogenic index, insulin resistance