Effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats

Authors : Javad MEHRABANİ, Maryam SEDİGHİANRAD, Nasrin RAMEZANİ, Hadi NOBARİ, Reza BAGHERİ

Pages : 43-48

View : 13 | Download : 8

Publication Date : 2017-09-30

Article Type : Research Paper

Abstract :The hypothalamus is a strong central controller of appetite that secretes different neuropeptides including AGRP. Plasma levels of AGRP are effective in controlling obesity and hunger. Therefore, the current study was performed with the aim of investigating the effect of endurance training on plasma levels of AGRP and HOMA-IR in diabetic rats. The Current study was experimental by posttest and control group. Eighteen male Wistar rats insert ignore into journalissuearticles values(200-220 grams with 8-10 weeks); were randomly divided into the control group and diabetic training. Eight weeks endurance training program included in the group of animal diabetic training for 5 days per week insert ignore into journalissuearticles values(15-40); minutes at 50 to 65 percent of vo2max. To determine the serum concentrations of AGRP was used by ELISA. A comparison of two groups showed significantly increased plasma concentrations of AGRP insert ignore into journalissuearticles values(p=0.006); and insulin resistance index, decreased significantly insert ignore into journalissuearticles values(p=0.002); compared to the control group after eight weeks, endurance training. According to the results, increased plasma concentrations of AGRP can be attributed to the negative balance caused by training. This agent destroys the body`s energy balance and hypothalamus for balancing increases the secretion of AGRP. This neuropeptide is likely will cause higher fat metabolism. 
Keywords : Agouti related protein, endurance training, insulin resistance, diabetes