The Role of TRP and K+ Ion Channels in Analgesic Effect of NSAIDs

Authors : Rana ARSLAN, Nurcan BEKTAŞ

Pages : 301-307

View : 16 | Download : 10

Publication Date : 2018-12-28

Article Type : Research Paper

Abstract :Objective: We aimed to clarify the possible contributions of TRP and voltagedependent K+ channels to the analgesic effects of diclofenac, ketoprofen, etodolac, and dipyrone using the nonselective TRP channel blocker ruthenium red and the voltage-dependent K+ channel blocker insert ignore into journalissuearticles values(Kv7; KCNQ); XE 991, respectively. Methods: We assessed the changes in the antinociceptive effects of diclofenac insert ignore into journalissuearticles values(50 mg/kg, i.p.);, ketoprofen insert ignore into journalissuearticles values(50 mg/kg, i.p.);, etodolac insert ignore into journalissuearticles values(70 mg/kg, i.p.);, and dipyrone insert ignore into journalissuearticles values(500 mg/kg, i.p.); using ruthenium red insert ignore into journalissuearticles values(3 mg/kg, i.p.); and XE 991 insert ignore into journalissuearticles values(1 mg/kg, i.p.); before treatment in the hot plate, tail immersion, and writhing tests in mice. Results: In the tail immersion test, ruthenium red administration resulted in a significant reversal in the analgesic effects of dipyrone, etodolac, and ketoprofen. In the hot plate test, a significant reversal was observed in the analgesic effect of only dipyrone. In the tail immersion test, the administration of XE 991 induced a significant reversal in the analgesic effects of dipyrone and etodolac and a relative reversal in the analgesic effects of ketoprofen and diclofenac. In the hot plate test, XE 991 produced a significant reversal in the analgesic effect of only ketoprofen, whereas it caused a relative reversal in the analgesic effects of other tested nonsteroidal anti-inflammatory drugs insert ignore into journalissuearticles values(NSAIDs);. In the writhing test, no significant change was observed after either XE 991 or ruthenium red administration. Concusions: Modulation of TRP and K+ channels may be involved in the central analgesic effects of NSAIDs. The clarification of different action mechanisms of NSAIDs will contribute to new therapeutic approaches and provide guidance for new drug development studies.
Keywords : NSAIDs, TRP channel, potassium channels, analgesia