The Level of Serum C-Reactive Protein and Neutrophil Lymphocyte Ratio According to Thyroid Function Status

Authors : Fatih KAR, Zeynep Küskü KİRAZ, Evin KOCATÜRK, Sema USLU

Pages : 142-147

Doi:10.33808/clinexphealthsci.600151

View : 18 | Download : 12

Publication Date : 2020-06-29

Article Type : Research Paper

Abstract :Objective: We aimed to investigate neutrophil lymphocyte ratio insert ignore into journalissuearticles values(NLR);, leukocyte count insert ignore into journalissuearticles values(WBC);, mean platelet volume insert ignore into journalissuearticles values(MPV); and C-reactive protein levels insert ignore into journalissuearticles values(CRP); as inflammatory markers according to thyroid function status in hypo-hyperthyroidism patients. Methods: Data of patients insert ignore into journalissuearticles values(n=454, age>18); who applied to the Eskisehir Osmangazi University Hospital between March 2018 and December 2018 were evaluated retrospectively. There were 79 patients in hyperthyroidism group insert ignore into journalissuearticles values(TSH<0.27 μIU/ml, group I);, 297 patients in euthyroid group insert ignore into journalissuearticles values(TSH=0.27-4.2 μIU/ml, group II); and 78 patients in hypothyroidism group insert ignore into journalissuearticles values(TSH>4.2 μIU/ml, group III);. Results: Serum TSH, fT4, fT3, anti-TG and anti-TPO levels were found statistically different between groups insert ignore into journalissuearticles values(p<0.001); but there were no significant difference in WBC, NLR and MPV between groups. There was a positive correlation between the NLR and CRP insert ignore into journalissuearticles values(r=0,295, p<0.01);. In addition, NLR was positively correlated with WBC insert ignore into journalissuearticles values(r=0,412, p<0.001);. Serum CRP levels were statistically higher in group I insert ignore into journalissuearticles values(3.5 mg/L [1.50-11]); than group II insert ignore into journalissuearticles values(2.1 mg/L [0.86-5.42]);, insert ignore into journalissuearticles values(p<0.001);. Although CRP levels were higher in group III insert ignore into journalissuearticles values(2.5 mg/L [1.18-5.73]); than group II, there was no significant difference. CRP showed weak positive correlation with fT4 insert ignore into journalissuearticles values(r=0,118, p<0.05); and negative correlation with TSH insert ignore into journalissuearticles values(r=-0,108, p<0.05);. Conclusion: High CRP levels may play an important role in the evaluation of hyperthyroidism in terms of thyroid dysfunction observed in the present study.
Keywords : Hyperthyroidism, Hypothyroidsm, Inflammation, TSH, CRP