Salivary Levels of IL-21 as a Potential Marker of Stage III Grade C Periodontitis

Authors : Ayse Ege SELMAN, Nimet Gül GÖRGÜLÜ, Başak DOĞAN

Pages : 878-883

Doi:10.33808/clinexphealthsci.989487

View : 20 | Download : 11

Publication Date : 2021-10-26

Article Type : Research Paper

Abstract :Objective: The onset, severity and progression of periodontal diseases are mainly related to the inflammatory host response against periodontal pathogens. The aim of this study was to evaluate salivary interleukin insert ignore into journalissuearticles values(IL); -1β, IL-13, IL-21 and IL-33 levels in patients with stage III grade C periodontitis and compare it with periodontally healthy individuals. Methods: A total of 58 individuals, including 28 periodontally healthy and 30 stage III grade C periodontitis patients were included in this study. Periodontal parameters including plaque index insert ignore into journalissuearticles values(PI);, gingival index insert ignore into journalissuearticles values(GI);, bleeding on probing insert ignore into journalissuearticles values(BOP);, probing depth insert ignore into journalissuearticles values(PD); and clinical attachment level insert ignore into journalissuearticles values(CAL); were measured. Saliva samples were obtained from all patients. Salivary interleukin insert ignore into journalissuearticles values(IL); -1β, IL-13, IL21, IL-33 levels were assessed using enzyme-linked immunosorbent assay insert ignore into journalissuearticles values(ELISA);. Results: All clinical parameters were significantly higher in periodontitis patients compared to healthy individuals insert ignore into journalissuearticles values(p<0.001);. Elevated salivary IL-1β and IL-21 levels were found in the periodontitis group compared to healthy ones insert ignore into journalissuearticles values(p=0.009 and p<0.001, respectively);. However, IL-13 and IL-33 levels were similar in both groups insert ignore into journalissuearticles values(p= 0.92);. IL-1β was significantly correlated with both clinical and biochemical parameters but IL-21 was correlated with only clinical parameters. Conclusion: This study showed that elevated salivary IL-21 and IL-1β levels are associated with periodontitis and might be used as a marker for the diagnosis of periodontitis.
Keywords : Periodontitis, interleukin 1 beta, interleukin 13, interleukin 21, interleukin 33