Antimicrobial Effect of Polyhexanide on Denture Base and Soft Lining Materials

Authors : Doğukan YILMAZ, Hakan AKIN

Pages : 113-119

Doi:10.33808/clinexphealthsci.833576

View : 21 | Download : 7

Publication Date : 2022-03-30

Article Type : Research Paper

Abstract :Objective: Polyhexanide insert ignore into journalissuearticles values(PHMB; polyhexamethylene biguanide); is a well-known antiseptic agent; however, no data exist for its application on denture base and lining materials. In the present in vitro study, the aim was to compare viable bacterial or fungal cell numbers and their adhesion on different types of denture base and lining materials in diverse concentrations of PHMB. Methods: Light-activated urethane dimethacrylate insert ignore into journalissuearticles values(UDMA);, heat-polymerized polymethyl methacrylate insert ignore into journalissuearticles values(PMMA);, heat-polymerized polydimethylsiloxane, and autopolymerizing polyethylmethacrylate discs were prepared for each group insert ignore into journalissuearticles values(n = 10);. 1×108 CFU/mL of all the tested species were appended separately to discs, and they were immersed into different PHMB suspensions insert ignore into journalissuearticles values(0.5%, 1%, 2%, and 5%); for 10 minutes. The antimicrobial activity and number of adherent species on the surface were evaluated. Results: In the PMMA group, all studied species except C. albicans, L. acidophilus, and S. aureus were decreased in various concentrations insert ignore into journalissuearticles values(p < 0.05);, and all studied species presented a significant decrease in every concentration of PHMB in the UDMA group insert ignore into journalissuearticles values(p < 0.01); in comparison to the control. N. sicca, K. pneumoniae, S. pyogenes, S. sanguis, C. pseudotuberculosis, and S. aureus insert ignore into journalissuearticles values(p < 0.05); were reduced in the heat-polymerized polydimethylsiloxane group, while all tested species except B. subtilis were decreased in the autopolymerizing polyethylmethacrylate group in comparison to the control insert ignore into journalissuearticles values(p < 0.01);. Among all tested materials and species, no significant difference was detected in adherent cell number insert ignore into journalissuearticles values(p > 0.05);. Conclusion: PHMB suspension, in various concentrations, can reduce some species of bacterial and yeast cells.
Keywords : Disinfectant, bacterial growth, denture adhesive, denture base