The Antiepileptic and Antidepressant-Like Effects of Dexpanthenol in Female Swiss Albino Mice

Authors : Salim İNAN, Yağmur AÇIKGÖZ

Pages : 141-144

Doi:10.33808/clinexphealthsci.865421

View : 14 | Download : 7

Publication Date : 2022-03-30

Article Type : Research Paper

Abstract :Objective: Oxidative stress is one of the main mechanisms of epilepsy and depression. Based on our information, behavioral effects of dexpanthenol in animals have not yet been demonstrated. Dexpanthenol itself is a topical medicine to restore skin barrier against infections caused by microorganisms which also stimulates the peristaltic movements in the gut when administered parenterally; however since it is cheap and easy to use with minor side effects, the main idea of the current research was to evaluate whether dexpanthenol has an antiepileptic and/or antidepressant-like effects. Methods: A group of female Swiss albino mice insert ignore into journalissuearticles values(25-30 g); were injected with dexpanthenol insert ignore into journalissuearticles values(ip, N = 8); or saline insert ignore into journalissuearticles values(ip, N = 8);, and 30 min later pentylenetetrazole insert ignore into journalissuearticles values(65 mg/kg, ip);-induced convulsions were determined for 30 min. In addition, another group of mice were again injected with dexpanthenol insert ignore into journalissuearticles values(500 mg/kg, ip, N = 8); or saline insert ignore into journalissuearticles values(ip, N = 8); and immobility time were evaluated in the forced swim test. Finally, mouse righting reflex test was used to assess the possible changes in motor coordination. Results: Our data showed that dexpanthenol, at the dose of 500 mg/kg displayed significant antiepileptic and antidepressant-like effects without affecting motor behavior. Conclusions: A common low-cost topical drug for various skin disorders that can also be given parenterally for motility regulation has an antiepileptic and antidepressant-like activity in mice.
Keywords : Epilepsy, Depression, Dexpanthenol, Mice