Measurements the Level of Lipid Peroxidation and Some Antioxidants in Blood Serum of Thalassemia’s Patients

Authors : Saba Z. AL-ABACHI, Sameer AL-GORANY, Abdulrazzaq ALTUWAIJARI, Jaafar GHAZY

Pages : 225-230

Doi:10.55549/epstem.1068616

View : 14 | Download : 5

Publication Date : 2021-12-31

Article Type : Research Paper

Abstract :Repeated blood transfusion in beta thalassemia patients may lead to peroxidative tissue injury by secondary iron overload. In the present study, insert ignore into journalissuearticles values(43); patients with beta thalassemia. We have evaluated hemoglobin insert ignore into journalissuearticles values(Hb);, packed cell volume insert ignore into journalissuearticles values(PCV);, red blood cells insert ignore into journalissuearticles values(RBC);, white blood cells insert ignore into journalissuearticles values(WBC);, iron insert ignore into journalissuearticles values(Fe);, ferriten, uric acid, glutathion insert ignore into journalissuearticles values(GSH);, malondialdehyde insert ignore into journalissuearticles values(MDA);, Vitamins C and E and electrolytes as sodium insert ignore into journalissuearticles values(Na);, potassium insert ignore into journalissuearticles values(K);, and chloride insert ignore into journalissuearticles values(Cl);. The findings were compared with insert ignore into journalissuearticles values(25); age matched healthy individuals were included in this study as a control group. A significant increase in the levels of WBC, Fe, ferritin, MDA and Vit C insert ignore into journalissuearticles values(P < 0.001);, whereas significant decrease in the levels of Hb, PCV, RBC, GSH and Vit E insert ignore into journalissuearticles values(P < 0.001); was observed. Uric acid, Na and K were significant increase insert ignore into journalissuearticles values(P < 0.05); in the patients when compared with controls, while there was a non-significant increase in mean value of Cl. These results were suggesting that oxidative stress and reduced antioxidant defense mechanism play an important role in pathogenesis of beta thalassemia major. We can conclude that defective membrane transport is responsible for observed changes of lipid peroxidation and some antioxidants. These results may help to understand the altered electrolyte homeostasis in thalassemia but there is still need of many future studies to clarify their mechanism of generation and pathological significance.
Keywords : Antioxidant, Beta thalassemia, Hemoglobin, Glutathion, Malondialdehyde