Relationship between Withdrawal Severity and Inflammation Parameters during the Detoxification Treatment of Alcohol Use Disorder

Authors : Gamze ZENGİN İSPİR, Rıza Gökçer TULACI

Pages : 23-30

Doi:10.51982/bagimli.1300547

View : 72 | Download : 102

Publication Date : 2024-03-31

Article Type : Research Paper

Abstract :Objective: Alcohol withdrawal is a potentially life-threatening condition that could be seen after discontinuation or a decrease in alcohol consumption. Inflammatory processes take part in alcohol withdrawal duration. This study aimed to investigate the relationship between withdrawal severity and inflammation parameters. Method: This retrospective study was performed via electronic health records in an alcohol and drug treatment center between August-2021 and August-2022. One hundred forty-one inpatients with alcohol use disorder and 134 controls were enrolled. Sociodemographic, clinical, and biochemical data of the participants were collected. Results: The patients and the control group were similar in age, gender, and educational status. The patients’ group had higher levels of neutrophils and lower levels of lymphocytes than the control group. Neutrophil-to-lymphocyte insert ignore into journalissuearticles values(NLR); and monocyte-to-lymphocyte ratio insert ignore into journalissuearticles values(MLR); levels were higher in the patients’ group. The alcohol withdrawal severity of patients was positively correlated with NLR levels, MLR levels, the amount of daily alcohol, and years of heavy alcohol consumption. Conclusion: NLR and MLR are inexpensive and easily accessible markers that could be used to estimate alcohol withdrawal severity.
Keywords : alkol ilişkili bozukluklar, inflammasyon, nötrofil, lenfosit, alkol yoksunluk semptomları