Depression and Anxiety in Patients with Multiple Sclerosis: A Retrospective Study on the Impact of Glatiramer Acetate

Authors : Ali Ulvi UCA, Faruk Ömer ODABAŞ, Mustafa ALTAŞ, Faruk UGUZ, Osman Serhat TOKGÖZ

Pages : 1-10

View : 14 | Download : 7

Publication Date : 2021-06-30

Article Type : Research Paper

Abstract :Objective: It has been reported that of disease-modifying therapies used in treatment of relapsing-remitting MS insert ignore into journalissuearticles values(RRMS); may affect mood of the patients. This study aims to investigate the impact of glatiramer acetate insert ignore into journalissuearticles values(GA); on depressive and anxiety symptoms in patients with RRMS. Methods: The study included 31 patients who were admitted to the neurology clinic, and who were diagnosed with RRMS. To assess depressive and anxiety symptoms in the patients before and after the treatment with GA was used the Center Epidemiologic Studies Depression Scale insert ignore into journalissuearticles values(CES-D); and the Hospital Anxiety and Depression Scale insert ignore into journalissuearticles values(HAD);, respectively. Results: Before the treatment, based on the scales CES-D and HAD-Depression scores, 18 insert ignore into journalissuearticles values(58.1%); and 17 insert ignore into journalissuearticles values(54.8%); patients had depression, respectively and based on HAD-Anxiety 15 insert ignore into journalissuearticles values(48.4%); patients had anxiety. After the treatment, the same numbers were 8 insert ignore into journalissuearticles values(25.8%);, 9 insert ignore into journalissuearticles values(29.0%);, and 7 insert ignore into journalissuearticles values(22.6%);, respectively. The statistical analyses indicated that the mean scores of CES-D insert ignore into journalissuearticles values(t=4.51, P=0.000);, HAD-Depression insert ignore into journalissuearticles values(t=2.91, P=0.007);, HAD-Anxiety insert ignore into journalissuearticles values(t=2.78, P=0.009); and HAD-Total insert ignore into journalissuearticles values(t=3.15, P=0.004); significantly decreased from the onset of treatment to the end of treatment. Conclusion: Results of the present study suggest that GA may be useful effects on depressive and anxiety symptoms rather than negative effects in RRMS patients.
Keywords : Multiple sclerosis, glatiramer acetate, depression, anxiety